Endocrine Abstracts

Introduction: Asprosin, a novel adipokine, is a circulating hormone mainly secreted by white adipose tissue. Asprosin is encoded by the penultimate 2 exons of the fibrillin 1 (FBN1) gene. Protein product of FBN1 is profibrillin-1, which undergoes a proteolytic cleavage by furin enzyme to produce mature fibrillin-1 and asprosin. Literature data indicated that asprosin is involved in the development of diabetes, obesity, cardiomyopathy, cancer, and polycystic o...

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy affecting reproductive-aged women, is characterized by oligo-/anovulation, hyperandrogenism and polycystic ovaries. In PCOS women with anovulatory infertility, the accepted first-line treatment is clomiphene citrate (CC). For patients resistant to CC, laparoscopic ovarian drilling (LOD) is recommended as a second-line therapy. Whilst very effective, LOD is an invasive technique requiring general anaesthesia and a...

Polycystic Ovary Syndrome (PCOS), the most common endocrinopathy of reproductive-age women, was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 NIH). Since Rotterdam Consensus Conference in 2003, its diagnosis requires the presence of at least two of the following features: oligo-/anovulation, hyperandrogenism and polycystic ovaries on ultrasound. However, since its introduction, this definition was strongly challenged...

Introduction: Polycystic Ovary Syndrome (PCOS) is a very common endocrinopathy affecting 6 to 13% of women of reproductive age and one of the leading causes of female poor fertility. It was initially defined by the association of anovulation and clinical and/or biochemical hyperandrogenism (1990 National Institutes of Health-sponsored conference). Since Rotterdam ESHRE/ASRM Consensus Conference in 2003, polycystic ovaries morphology on ultrasound (ECHO condition) was added as ...

Diet, and especially metabolic dysregulation such as obesity can influence the ovarian activity. Adipose tissue plays an important role since it is known to be one of the most important endocrine organs producing hundreds of cytokines, such as adiponectin. Our team has observed that adiponectin modulated steroid secretion by the ovarian granulosa cells and its concentration in the follicular fluid was influenced by the metabolic status. Recently, a small adiponectin mimetic sy...

Adiponectin is a protein hormone mainly produced by adipocytes. It plays an essential role in the regulation of lipid and carbohydrate metabolisms. Adiponectin mediates its effects through mainly two receptors named AdipoR1 and AdipoR2. Some evidence in rodent and domestic animals suggests that adiponectin could also regulate female fertility and more particularly ovarian functions. However, its role in human ovary has never been investigated. The objectives of the present stu...

Adiponectin is one of the most abundant fat-derived hormones involved in a multitude of metabolism pathways. It acts as an anti-diabetic and anti-atherogenic adipokine. Adiponectin mediates its actions through mainly two receptors, AdipoR1 and AdipoR2. It has been postulated that although AdipoR1 and AdipoR2 consist of seven transmembrane helices, they are distinct from other G protein-coupled receptors. A role of adiponectin in ovarian physiology has been recently suggested. ...

Introduction: Omentin, also known as intelectin-1 (ITLN1), is a novel adipokine produced predominantly by visceral adipose tissue, which improves insulin sensitivity. Decreased levels of ITLN1 have been reported in the serum of obese and polycystic ovary syndrome patients, as well as in the serum and adipose tissue of obese Meishan (MS) compared to normal weight Large White (LW) pigs. However, the role of ITLN1 in female reproduction at different metabolic status is still unkn...

Background : Omentin, also known as intelectin-1, is a member of the family of adipose tissue-related hormones known as adipokines, that exert anti-inflammatory, anti-atherosclerotic, and cardiovascular protective effects. Omentin expression has been detected in adipocytes as well as in a variety of extra-adipose tissues, including the ovary. Interestingly, omentin expression in the pituitary has been shown to be regulated by pituitary hormones. These observations led us to in...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...